cytotoxic activity of bioactive compound 1, 2- benzene dicarboxylic acid, mono 2- ethylhexyl ester extracted from a marine derived streptomyces sp. vitsjk8
Authors
abstract
marine streptomyces are prolific producers of majority of bioactive secondary metabolites which are used in pharmaceutical industry as effective drugs against life threatening diseases. the cytotoxic activity of the pure compound 1, 2- benzene dicarboxylic acid, mono 2- ethylhexyl ester (dmehe) from marine derived actinomycete streptomyces sp. vitsjk8 was investigated against mouse embryonic fibroblast (nih 3t3) and human keratinocyte (hacat) normal cell lines, human hepatocellular liver carcinoma (hepg 2) and human breast adenocarcinoma (mcf-7) cell lines by using mtt assay. the compound dmehe exhibited ic 50 values of 42, 100, 250 and 500 µg/ ml against hepg2, mcf-7, hacat and nih 3t3 cell lines, respectively. the effect of dmehe on the growth of cancer cell lines was expressed as the % of viability. cell viability was recorded as 67.7%, 78.14%, 82.23% and 96. 11% in hepg2, mcf-7, hacat and nih 3t3 cells, respectively. the results of the study conclude that the bioactive compound isolated from the potential isolate streptomyces sp. vitsjk8 exhibited cytotoxic activity against hepg2 and mcf- 7 cancer cell lines and low toxicity against normal hacat and nih 3t3 cell lines.
similar resources
Cytotoxic Activity of Bioactive Compound 1, 2- Benzene Dicarboxylic Acid, Mono 2- Ethylhexyl Ester Extracted from a Marine Derived Streptomyces sp. VITSJK8
Marine Streptomyces are prolific producers of majority of bioactive secondary metabolites which are used in pharmaceutical industry as effective drugs against life threatening diseases. The cytotoxic activity of the pure compound 1, 2- benzene dicarboxylic acid, mono 2- ethylhexyl ester (DMEHE) from marine derived actinomycete Streptomyces sp. VITSJK8 was investigated against mouse embryonic fi...
full textCytotoxic Activity of Bioactive Compound 1, 2- Benzene Dicarboxylic Acid, Mono 2- Ethylhexyl Ester Extracted from a Marine Derived Streptomyces sp. VITSJK8
Marine Streptomyces are prolific producers of majority of bioactive secondary metabolites which are used in pharmaceutical industry as effective drugs against life threatening diseases. The cytotoxic activity of the pure compound 1, 2- benzene dicarboxylic acid, mono 2- ethylhexyl ester (DMEHE) from marine derived actinomycete Streptomyces sp. VITSJK8 was investigated against mouse embryonic fi...
full textIn Silico Analysis of Streptomyces Sp Secondary Metabolite 1, 2-benzenedicarboxylic Acid, Mono (2-ethylhexyl) Ester with Esbl Proteins
The anti-ESBL activity of 1, 2-benzenedicarboxylic acid, mono (2-ethylhexyl) ester (DMEHE) extracted from marine Streptomyces sp strain VITSJK8 was further confirmed by in silico analysis. A total of 10 ESBL proteins was chosen for this study from the protein data bank (PDB) and were docked with the DMEHE. The resultant atomic contact energy (ACE) was compared with dockings of known antibiotic ...
full textBenzene-1,4-dicarboxylic acid–N,N-dimethylacetamide (1/2)
The asymmetric unit of title compound, C(8)H(6)O(4)·2C(4)H(9)NO, contains one half-mol-ecule (an inversion centre in P21/n generates the other half of the molecule) of terephthalic acid (TA) and one mol-ecule of N,N-dimethyl-acetamide (DMAC). The DMAC mol-ecules are linked to TA by strong O-H⋯O hydrogen bonds.
full textAnti-MRSA activity of a bioactive compound produced by a marine Streptomyces and its optimization using statistical experimental design
Objective(s): To address the alarming problem of methicillin-resistant Staphylococcus aureus (MRSA), herein, a marine Streptomyces capable of producing an anti-MRSA compound has been studied.Materials and Methods: Strain MN41 was morphologically and physiologically characterized and then, molecularly identified using 16SrRNA analysis. To...
full textBioactive 2(1H)-Pyrazinones and Diketopiperazine Alkaloids from a Tunicate-Derived Actinomycete Streptomyces sp.
As a part of our ongoing effort to allocate marine microbial bioactive leads, a tunicate-derived actinomycete, Streptomyces sp. Did-27, was investigated. Three new 2(1H)-pyrazinones derivatives, (S)-6-(sec-butyl)-3-isopropylpyrazin-2(1H)-one (1), (S)-3-(sec-butyl)-6-isopropylpyrazin-2(1H)-one (2) and (S)-6-(sec-butyl)-3-isobutylpyrazin-2(1H)-one (3), together with the known (1H)-pyrazinones ana...
full textMy Resources
Save resource for easier access later
Journal title:
international journal of molecular and cellular medicineجلد ۳، شماره ۴، صفحات ۲۴۶-۲۵۴
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023